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Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade
These changes can cause oxidative modifications to reactive thiols of structurally- or functionally-critical proteins, such as transcription factors 43 , signal transduction molecules 44 or metabolic enzymes 45 , and thereby evoke cellular defense mechanisms against oxidative damage 46
doi: 10.1093/oxfordjournals.aje.a010290 43
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